Endocrine Abstracts

Some steroids modulate the permeability of ionotropic receptors on cell membranes and therefore may activate or inhibit neuronal activity depending on the steroid structure. These neuroactive steroids (NAS) exert neuroprotective effects like the neuronal remyelination.Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Therefore, the authors have followed the neuroprotective, GABAergic, glycinergic, glutamatergic ...

Multiple sclerosis (MS) is a common inflammatory autoimmune and demyelinating disease of the central nervous system (CNS) that compromises health and leads to disability. Sex differences in the prevalence and progression of MS suggest the involvement of sex steroids in the pathophysiology of MS. In late pregnancy, at the highest levels of progesterone and estradiol, the number of relapses decreases and increases again after delivery due to changes in steroid levels. In additio...